Detecting hepatitis B surface antigen mutants

被引：105

作者：

Coleman, PF ^{[1
]}

机构：

[1] Abbott Labs, Abbott Pk, IL 60064 USA

来源：

EMERGING INFECTIOUS DISEASES | 2006年 / 12卷 / 02期

关键词：

D O I：

10.3201/eid1203.050038

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels. HBsAg mutants present as false-negative results in some immunoassays. An understanding of immunoassay reactivity with HBsAg mutants is key to establishing an appropriate testing algorithm for hepatitis B virus detection programs.

引用

页码：198 / 203

页数：6

共 47 条

[1]

SITE-DIRECTED MUTAGENESIS OF CYSTEINE RESIDUES OF HEPATITIS-B SURFACE-ANTIGEN ANALYSIS OF 2 SINGLE MUTANTS AND THE DOUBLE MUTANT [J].