High-performance liquid chromatography-diode array detection-tandem mass spectrometry analyses of the alkaloid extracts of Amazon Psychotria species

被引:29
作者
Verotta, L
Peterlongo, F
Elisabetsky, E
Amador, TA
Nunes, DS
机构
[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
[2] Indena SPA, Lab Ricerca & Sviluppo, Milan, Italy
[3] Univ Fed Rio Grande do Sul, Dept Farmacol, Porto Alegre, RS, Brazil
[4] Univ Estadual Ponta Grossa, Dept Quim, Ponta Grossa, Parana, Brazil
关键词
Psychotria; plant materials; alkaloids;
D O I
10.1016/S0021-9673(99)00298-8
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
High-performance liquid chromatography paired with UV photodiode array, electrospray MS-MS and thermospray MS detectors was investigated as a method for the analysis of alkaloids in different parts of Psychotria spp. collected in the Amazon. Nine products have been isolated from the vegetable material and their structures elucidated by spectroscopic means. These constituents indicate pyrrolidinoindoline and quinoline alkaloid classes. Minor components were also assigned through MS fragmentations. Place and period of collections of the plant materials are responsible for both qualitative and quantitative variations with respect to pyrrolidinoindoline and quinoline type alkaloids. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:165 / 176
页数:12
相关论文
共 10 条
[1]   Effects of Psychotria colorata alkaloids in brain opioid system [J].
Amador, TA ;
Elisabetsky, E ;
deSouza, DO .
NEUROCHEMICAL RESEARCH, 1996, 21 (01) :97-102
[2]  
BALAYER A, 1993, NAT PROD LETT, V0002
[3]  
ELISABETSKY E, 1990, International Journal of Crude Drug Research, V28, P309
[4]   ANALGESIC ACTIVITY OF PSYCHOTRIA-COLORATA (WILLD EX R-AND-S) MUELL ARG ALKALOIDS [J].
ELISABETSKY, E ;
AMADOR, TA ;
ALBUQUERQUE, RR ;
NUNES, DS ;
CARVALHO, ADT .
JOURNAL OF ETHNOPHARMACOLOGY, 1995, 48 (02) :77-83
[5]  
ELISABETSKY E, 1997, J BRAZILIAN ASS ADV, V49, P379
[6]   BIOGENETIC-TYPE SYNTHESIS OF CALYCANTHACEOUS ALKALOIDS [J].
HALL, ES ;
MCCAPRA, F ;
SCOTT, AI .
TETRAHEDRON, 1967, 23 (10) :4131-&
[7]   PSYCHOTRIDINE, A C55H62N10 ALKALOID FROM PSYCHOTRIA-BECCARIOIDES (RUBIACEAE) [J].
HART, NK ;
JOHNS, SR ;
LAMBERTON, JA ;
SUMMONS, RE .
AUSTRALIAN JOURNAL OF CHEMISTRY, 1974, 27 (03) :639-646
[8]  
LIBOT F, 1988, HETEROCYCLES, V27, P2381
[9]   QUADRIGEMINES-A AND QUADRIGEMINES-B, 2 MINOR ALKALOIDS OF HODGKINSONIA-FRUTESCENS F-MUELL [J].
PARRY, KP ;
SMITH, GF .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1978, (12) :1671-1682
[10]   Pyrrolidinoindoline alkaloids from Psychotria colorata [J].
Verotta, L ;
Pilati, T ;
Tatò, M ;
Elisabetsky, E ;
Amador, TA ;
Nunes, DS .
JOURNAL OF NATURAL PRODUCTS, 1998, 61 (03) :392-396