Adipose proteome analysis: focus on mediators of insulin resistance

被引：25

作者：

Chen, Xiaoli ^{[1
]}

Hess, Sonja ^{[2
]}

机构：

[1] Univ Minnesota Food Sci & Nutr, St Paul, MN 55108 USA

[2] CALTECH, Proteome Explorat Lab, Pasadena, CA 91125 USA

来源：

EXPERT REVIEW OF PROTEOMICS | 2008年 / 5卷 / 06期

关键词：

adipocyte; adipokine; diabetes; insulin resistance; insulin signaling pathway; phosphoproteome; phosphorylation; proteomics; secretome;

D O I：

10.1586/14789450.5.6.827

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

As is well known, adipose tissue is an important site for lipid metabolism and insulin-responsive glucose uptake. The recent discovery of the endocrine function of adipose tissue and the association of obesity with chronic low-grade inflammation in adipose tissue has reinforced the concept of the central role of adipose tissue in mediating obesity-linked insulin resistance and metabolic dysregulation. The study of adipose cells has provided new insights into the mechanism underlying insulin resistance as well as the therapeutic strategies for diabetes. Numerous efforts have been made in identifying key molecular regulators of insulin action and metabolism, including the utilization of advanced proteomics technology. Various proteomic approaches have been applied to identify the adipose secretome, protein-expression profiling and post-translational modifications in adipose cells in the pathological state. In this review, we summarize the recent advances in the proteomics of adipose tissue, and discuss the identified proteins that potentially play important roles in insulin resistance and diabetes.

引用

页码：827 / 839

页数：13

共 103 条

[1] In-depth analysis of the adipocyte proteome by mass spectrometry and bioinformatics [J].

Adachi, Jun ;

Kumar, Chanchal ;

Zhang, Yanling ;

Mann, Matthias .

MOLECULAR & CELLULAR PROTEOMICS, 2007, 6 (07) :1257-1273

[2] Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action [J].

Aguirre, V ;

Werner, ED ;

Giraud, J ;

Lee, YH ;

Shoelson, SE ;

White, MF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (02) :1531-1537

[3] The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307 [J].

Aguirre, V ;

Uchida, T ;

Yenush, L ;

Davis, R ;

White, MF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (12) :9047-9054

[4] Characterization of the human visceral adipose tissue secretome [J].

Alvarez-Llamas, Gloria ;

Szalowska, Ewa ;

de Vries, Marcel P. ;

Weening, Desiree ;

Landman, Karloes ;

Hoek, Annemieke ;

Wolffenbuttel, Bruce H. R. ;

Roelofsen, Han ;

Vonk, Roel J. .

MOLECULAR & CELLULAR PROTEOMICS, 2007, 6 (04) :589-600

[5] In vivo modulation of Hmgic reduces obesity [J].

Anand, A ;

Chada, K .

NATURE GENETICS, 2000, 24 (04) :377-380

[6] Resistin: yet another adipokine tells us that men are not mice [J].

Arner, P .

DIABETOLOGIA, 2005, 48 (11) :2203-2205

[7] Regulation of fasted blood glucose by resistin [J].

Banerjee, RR ;

Rangwala, SM ;

Shapiro, JS ;

Rich, AS ;

Rhoades, B ;

Qi, Y ;

Wang, J ;

Rajala, MW ;

Pocai, A ;

Scherer, PE ;

Steppan, CM ;

Ahima, RS ;

Obici, S ;

Rossetti, L ;

Lazar, MA .

SCIENCE, 2004, 303 (5661) :1195-1198

[8] Adipose tissue, inflammation, and cardiovascular disease [J].

Berg, AH ;

Scherer, PE .

CIRCULATION RESEARCH, 2005, 96 (09) :939-949

[9] Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury [J].

Berger, T ;

Togawa, A ;

Duncan, GS ;

Elia, AJ ;

You-Ten, A ;

Wakeham, A ;

Fong, HEH ;

Cheung, CC ;

Mak, TW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (06) :1834-1839

[10] Phosphoproteomic analysis of Her2/neu signaling and inhibition [J].

Bose, Ron ;

Molina, Henrik ;

Patterson, A. Scott ;

Bitok, John K. ;

Periaswamy, Balamurugan ;

Bader, Joel S. ;

Pandey, Akhilesh ;

Cole, Philip A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (26) :9773-9778

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