Tolerance to vascularized organ allografts in large-animal models

被引：41

作者：

Kawai, T

Sachs, DH

Cosimi, AB

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Surg, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Transplantat Biol Res Ctr, Boston, MA 02129 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(99)00009-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although studies of tolerance induction in large animals remain limited compared with murine studies, a number of encouraging observations have been recently reported - especially in nonhuman primate models. The development of antibodies or proteins binding to costimulatory molecules and of an immunotoxin that is active on T cells have been particularly important advances leading to expanded opportunities for extending strategies for tolerance induction to large animals.

引用

页码：516 / 520

页数：5

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