Short report:: Impact of ivermectin community-level treatments on elimination of adult Onchocerca volvulus when individuals receive multiple treatments per year

被引：43

作者：

Cupp, EW ^{[1
]}

Cupp, MS ^{[1
]}

机构：

[1] Auburn Univ, Dept Entomol & Plant Pathol, Auburn, AL 36849 USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2005年 / 73卷 / 06期

关键词：

D O I：

10.4269/ajtmh.2005.73.1159

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A reanalysis of several published reports indicates that when community-wide biannual treatment disrupts transmission of new infection, a profound macrofilaricidal effect of ivermectin (Mectizan) occurs that is accelerated for individuals treated 4 times a year (4x/yr). The effect is particularly obvious on adult male worms and suggests that this gender is susceptible to repetitive treatment after transmission has been blocked or greatly reduced as a result of community treatment.

引用

页码：1159 / 1161

页数：3

共 12 条

[1] THE IMPACT OF 5 YEARS OF ANNUAL IVERMECTIN TREATMENT ON SKIN MICROFILARIAL LOADS IN THE ONCHOCERCIASIS FOCUS OF ASUBENDE, GHANA [J].

ALLEY, ES ;

PLAISIER, AP ;

BOATIN, BA ;

DADZIE, KY ;

REMME, J ;

ZERBO, G ;

SAMBA, EM .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1994, 88 (05) :581-584

[2]

BUTTNER DW, 1988, TROP MED PARASITOL, V39, P73

[3]

Cupp EW, 2004, AM J TROP MED HYG, V71, P602

[4] THE EFFECTS OF REPETITIVE COMMUNITY-WIDE IVERMECTIN TREATMENT ON TRANSMISSION OF ONCHOCERCA-VOLVULUS IN GUATEMALA [J].

CUPP, EW ;

OCHOA, JO ;

COLLINS, RC ;

CUPP, MS ;

GONZALESPERALTA, C ;

CASTRO, J ;

ZEAFLORES, G .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1992, 47 (02) :170-180

[5] EFFECTS OF 3-MONTH DOSES OF IVERMECTIN ON ADULT ONCHOCERCA-VOLVULUS [J].

DUKE, BOL ;

ZEAFLORES, G ;

CASTRO, J ;

CUPP, EW ;

MUNOZ, B .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1992, 46 (02) :189-194

[6] COMPARISON OF THE EFFECTS OF A SINGLE DOSE AND OF 4 6-MONTHLY DOSES OF IVERMECTIN ON ADULT ONCHOCERCA-VOLVULUS [J].

DUKE, BOL ;

ZEAFLORES, G ;

CASTRO, J ;

CUPP, EW ;

MUNOZ, B .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1991, 45 (01) :132-137

[7] Effects of standard and high doses of ivermectin on adult worms of Onchocerca volvulus:: a randomised controlled trial [J].

Gardon, J ;

Boussinesq, M ;

Kamgno, J ;

Gardon-Wendel, N ;

Demanga-Ngangue ;

Duke, BOL .

LANCET, 2002, 360 (9328) :203-210

[8] COMPARISON OF IVERMECTIN AND DIETHYLCARBAMAZINE IN THE TREATMENT OF ONCHOCERCIASIS [J].

GREENE, BM ;

TAYLOR, HR ;

CUPP, EW ;

MURPHY, RP ;

WHITE, AT ;

AZIZ, MA ;

SCHULZKEY, H ;

DANNA, SA ;

NEWLAND, HS ;

GOLDSCHMIDT, LP ;

AUER, C ;

HANSON, AP ;

FREEMAN, SV ;

REBER, EW ;

WILLIAMS, PN .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (03) :133-138

[9] Successful control of onchocerciasis with community-based ivermectin distribution in the Rio Santiago focus in Ecuador [J].

Guderian, RH ;

Anselmi, M ;

Espinel, M ;

Mancero, T ;

Rivadeneira, G ;

Proano, R ;

Calvopina, HM ;

Vieira, JC ;

Cooper, PJ .

TROPICAL MEDICINE & INTERNATIONAL HEALTH, 1997, 2 (10) :982-988

[10] Programmatic goals and approaches to onchocerciasis [J].

Richards, F ;

Hopkins, D ;

Cupp, E .

LANCET, 2000, 355 (9216) :1663-1664

← 1 2 →