Organ dysfunction during sepsis

被引：50

作者：

Singh, S

Evans, TW

机构：

[1] Chelsea & Westminster Hosp, Dept Intens Care Med, London SW10 9NH, England

[2] Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Intens Care Med, Royal Brompton Hosp, London, England

来源：

INTENSIVE CARE MEDICINE | 2006年 / 32卷 / 03期

关键词：

multiple organ dysfunction syndrome; sepsis; microvascular dysfunction; cytopathic hypoxia; bioenergetic failure; scoring system;

D O I：

10.1007/s00134-005-0038-9

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: Multiple organ dysfunction syndrome is the commonest reason for sepsis-associated mortality. Discussion: In the 40 years since it was first described understanding of its pathophysiology has improved, and novel methodologies for monitoring and severity of illness scoring have emerged. These, together with the development of systematic strategies for managing organ dysfunction in sepsis, and potentially effective new therapeutic interventions, should assist in reducing sepsis-associated mortality. Conclusion: These historical developments are discussed, and the reader is directed to these references for further guidance.

引用

页码：349 / 360

页数：12

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