Influence of lignification and feruloylation of maize cell walls on the adsorption of heterocyclic aromatic amines

被引:23
作者
Funk, C
Weber, P
Thilker, J
Grabber, JH
Steinhart, H
Bunzel, M
机构
[1] Univ Hamburg, Inst Biochem & Food Chem, Dept Food Chem, D-20146 Hamburg, Germany
[2] USDA ARS, US Dairy Forage Res Ctr, Madison, WI 53706 USA
关键词
heterocyclic aromatic amines; carcinogens; adsorption studies; Zea mays; dehydrogenation polymer-cell wall complexes; lignin; monolignols; ferulates; diferulates;
D O I
10.1021/jf052275+
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Both epidemiological and experimental data indicate that a diet rich in fiber may reduce cancer risk. One possible mechanism is by adsorbing carcinogens and transporting them out of the body without metabolic activation. We investigated the role of fiber lignification and feruloylation on the adsorption of four of the most relevant heterocyclic aromatic amines in food: 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and 2-amino-9H-pyrido[2,3-b]indole (A alpha C). Adsorption experiments, under conditions mimicking the small intestine, were carried out using nonlignified and artificially lignified primary maize walls with defined lignin and ferulate/diferulate concentrations and defined lignin compositions. Lignin concentration and composition both influenced the adsorption of heterocyclic aromatic amines, especially the more hydrophobic types. Heterocyclic aromatic amine adsorption increased with lignin concentration. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-9H-pyrido[2,3-b]indole were better adsorbed by guaiacyl-rich lignins, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by syringyl-rich lignins, whereas the adsorption of 2-amino-3-methylimidazo[4,5-f]quinoline was not clearly influenced by lignin composition. Nonlignified cell walls adsorbed lesser amounts of heterocyclic aromatic amines. Variations in cell wall feruloylation had no effect on heterocyclic aromatic amine adsorption.
引用
收藏
页码:1860 / 1867
页数:8
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