Cardiorespiratory interactions during fixed-pace resistive breathing

被引:16
作者
Blaber, AP [1 ]
Hughson, RL [1 ]
机构
[1] UNIV WATERLOO,DEPT KINESIOL,WATERLOO,ON N2L 3G1,CANADA
关键词
respiratory sinus arrhythmia; baroreflex; pulsed Doppler ultrasound; stroke volume; cross-spectral analysis;
D O I
10.1152/jappl.1996.80.5.1618
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We tested the hypothesis that the arterial baroreflex was important in the origin of respiratory sinus arrhythmia (RSA) under conditions of normal and resistive breathing. That is, mechanical effects of breathing [indicated by instantaneous lung volume (ILV)] would directly influence left ventricular stroke volume (LVSV), which in turn would influence systolic arterial blood pressure (SABP), causing variation in R-R interval through the baroreflex. Eight healthy young subjects (four men and four women) were monitored in the supine position while breathing with a fixed frequency (0.2 Hz) and tidal volume for 15 min through each of three resistances (R(0), R(1), and R(2)) producing inspiratory (-) and expiratory (+) pressures of +/-1.6, + 5.4, and +/- 16.6 cmH(2)O, respectively. LVSV was estimated by stroke distance [(SDist); by Doppler ultrasound]. There were no differences across R(0), R(1), and R(2) for the mean values of R-R interval, SDist, or SABP. Cross-spectral analysis showed that, at R(0), each value of R-R interval, SDist, and SABP lagged ILV by similar to 80 degrees. At R(1) and R(2), phase was reduced from ILV to SDist and R-R interval, and the transfer magnitude for SDist (R(2) only), SABP, and R-R interval increased. The transfer magnitude from SDist to SABP significantly increased as a function of resistance breathing, whereas that from SABP to R-R interval significantly decreased. There were no changes in phase relationships from SDist to SABP to R-R interval. Thus the magnitude of RSA (ILV to R-R interval) was increased, but the transfer through the arterial baroreflex (SABP to R-R interval) was reduced. Although factors other than the arterial baroreflex are probably involved in the genesis of RSA, the constant phase relationship across the levels of breathing resistance among SDist, SABP, and R-R interval suggests an important functional link caused by mechanical effects of breathing.
引用
收藏
页码:1618 / 1626
页数:9
相关论文
共 25 条
[1]   BEAT TO BEAT VARIABILITY IN CARDIOVASCULAR VARIABLES - NOISE OR MUSIC [J].
APPEL, ML ;
BERGER, RD ;
SAUL, JP ;
SMITH, JM ;
COHEN, RJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1989, 14 (05) :1139-1148
[2]   MODEL FOR THE ASSESSMENT OF HEART PERIOD AND ARTERIAL-PRESSURE VARIABILITY INTERACTIONS AND OF RESPIRATION INFLUENCES [J].
BASELLI, G ;
CERUTTI, S ;
BADILINI, F ;
BIANCARDI, L ;
PORTA, A ;
PAGANI, M ;
LOMBARDI, F ;
RIMOLDI, O ;
FURLAN, R ;
MALLIANI, A .
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1994, 32 (02) :143-152
[3]  
BUTLER GC, 1990, AVIAT SPACE ENVIR MD, V61, P240
[4]   BAROREFLEX CONTROL OF STROKE VOLUME IN MAN - AN EFFECT MEDIATED BY THE VAGUS [J].
CASADEI, B ;
MEYER, TE ;
COATS, AJS ;
CONWAY, J ;
SLEIGHT, P .
JOURNAL OF PHYSIOLOGY-LONDON, 1992, 448 :539-550
[5]  
DEBOER RW, 1987, AM J PHYSIOL, V253, pH680
[6]   NONLINEARITIES OF THE HUMAN CAROTID BARORECEPTOR-CARDIAC REFLEX [J].
ECKBERG, DL .
CIRCULATION RESEARCH, 1980, 47 (02) :208-216
[7]  
ECKBERG DL, 1992, HUMAN BAROREFLEXES H, P61
[8]   IMPROVED METHOD FOR CARDIAC-OUTPUT DETERMINATION IN MAN USING ULTRASOUND DOPPLER TECHNIQUE [J].
ERIKSEN, M ;
WALLOE, L .
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1990, 28 (06) :555-560
[9]   RESPIRATORY SINUS ARRHYTHMIA IN HUMANS - HOW BREATHING PATTERN MODULATES HEART-RATE [J].
HIRSCH, JA ;
BISHOP, B .
AMERICAN JOURNAL OF PHYSIOLOGY, 1981, 241 (04) :H620-H629
[10]   INTERNAL CAROTID FLOW VELOCITY WITH EXERCISE BEFORE AND AFTER ACCLIMATIZATION TO 4,300-M [J].
HUANG, SY ;
TAWNEY, KW ;
BENDER, PR ;
GROVES, BM ;
MCCULLOUGH, RE ;
MCCULLOUGH, RG ;
MICCO, AJ ;
MANCOJOHNSON, M ;
CYMERMAN, A ;
GREENE, ER ;
REEVES, JT .
JOURNAL OF APPLIED PHYSIOLOGY, 1991, 71 (04) :1469-1476