Determination of Diazepam and associated compounds in pharmaceutical preparations

被引：7

作者：

Berzas, JJ ^{[1
]}

Castañeda, G ^{[1
]}

Pinilla, MJ ^{[1
]}

机构：

[1] Univ Castilla La Mancha, Fac Quim, Dept Quim Analit & Tecnol Alimentos, E-13071 Ciudad Real, Spain

来源：

FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY | 1999年 / 364卷 / 06期

关键词：

D O I：

10.1007/s002160051388

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学]; 081704 [应用化学];

摘要：

A method for determining Diazepam and its associated compounds in pharmaceutical products by micellar electrokinetic chromatography (MEKC) is described. The separation was carried out at 30 degrees C and 25 kV, using a 25 mM berate buffer (pH 9.6) and 35 mM sodium dodecylsulfate (SDS) water solution. Under these conditions the analysis was carried out within 12 min with acceptable limits of detection and quantification. The method has been applied for quantifying Diazepam in different commercial formulations when it is the active drug and when it is employed associated with other drugs (Nortriptyline, Pyridoxine hydrochloride and Sulpiride).

引用

页码：570 / 575

页数：6

共 18 条

[1]

APPROACHES TO OPTIMIZATION OF PRECISION IN CAPILLARY ELECTROPHORESIS [J].