Identification of a new quantitative trait locus on Chromosome 7 controlling disease severity of collagen-induced arthritis in rats

被引：30

作者：

Dracheva, SV

Remmers, EF

Gulko, PS

Kawahito, Y

Longman, RE

Reese, VR

Cannon, GW

Griffiths, MM

Wilder, RL

机构：

[1] NIAMSD, Inflammatory Joint Dis Sect, Arthrit & Rheumatism Branch, NIH, Bethesda, MD 20892 USA

[2] Univ Utah, Dept Med Rheumatol, Salt Lake City, UT 84132 USA

[3] Vet Affairs Med Ctr, Res Serv, Salt Lake City, UT 84148 USA

[4] Columbia Univ, Coll Phys & Surg, Div Autoimmune & Mol Dis, New York, NY 10032 USA

来源：

IMMUNOGENETICS | 1999年 / 49卷 / 09期

关键词：

rheumatoid arthritis; quantitative trait locus; inbred rats; linkage mapping; comparative maps;

D O I：

10.1007/s002510050552

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Autoimmune diseases, such as rheumatoid arthritis, Crohn's disease, and multiple sclerosis, are regulated by multiple genes. Major histocompatibility complex (MHC) genes have the strongest effects, but non-MHC genes also contribute to disease susceptibility/severity. In this paper, we describe a new non-MHC quantitative trait locus, Cia8, on rat Chromosome (Chr) 7 that controls collagen-induced arthritis severity in F2 progeny of DA and F344 inbred rats, and present an updated localization of Cia4 on the same chromosome. We also describe the location of mouse and human genes, orthologous to the genes in the genomic intervals containing Cia4 and Cia8, and provide evidence that the segment of rat Chr 7 containing Cia4 and Cia8 is homologous to segments of mouse Chr 10 and 15 and human Chr 8, 12, and 19.

引用

页码：787 / 791

页数：5

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