Migrating and myelinating potential of subventricular zone neural progenitor cells in white matter tracts of the adult rodent brain

被引:47
作者
Cayre, M [1 ]
Bancila, M [1 ]
Virard, I [1 ]
Borges, A [1 ]
Durbec, P [1 ]
机构
[1] Inst Biol Dev Marseille Luminy, UMR 6216, F-13288 Marseille 9, France
关键词
subventricular zone; graft; migration; oligodendrocyte; myelin repair; white matter;
D O I
10.1016/j.mcn.2006.01.004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Adult neural stem cells in the subventricular zone (SVZ) produce neuronal progenitors that migrate along the rostra[ migratory stream (RMS) and generate olfactory interneurons. Here, we evaluate the migratory potential of SVZ cells outside the RMS and their capacity to generate oligodendrocytes in the adult brain. We show that SVZ cells migrate long distances when grafted into white matter tracts such as the cingulum (Ci) and corpus callosum (CC). Furthermore, 22 days postinjection, most present morphologic and phenotypic characteristics of cells committed to the oligodendrocyte lineage. Cells grafted in shiverer CC and Ci become MBP-positive oligodendrocytes, abundant, myelinating these white matter tracts. Type A progenitors are involved in this myelinating process. Altogether, this study reveals the migrating and myelinating potential of SVZ cells in a new environmental context. Therefore, SVZ cells stand as interesting candidates for the development of novel therapeutic strategies for demyelinating diseases. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:748 / 758
页数:11
相关论文
共 36 条
[1]   Postnatal neurogenesis and gliogenesis in the olfactory bulb from NG2-expressing progenitors of the subventricular zone [J].
Aguirre, A ;
Gallo, V .
JOURNAL OF NEUROSCIENCE, 2004, 24 (46) :10530-10541
[2]   NG2-expressing cells in the subventricular zone are type C-like cells and contribute to interneuron generation in the postnatal hippocampus [J].
Aguirre, AA ;
Chittajallu, R ;
Belachew, S ;
Gallo, V .
JOURNAL OF CELL BIOLOGY, 2004, 165 (04) :575-589
[3]   Transplantation options for therapeutic central nervous system remyelination [J].
Blakemore, WF ;
Franklin, RJM .
CELL TRANSPLANTATION, 2000, 9 (02) :289-294
[4]  
Chazal G, 2000, J NEUROSCI, V20, P1446
[5]  
Chiasson BJ, 1999, J NEUROSCI, V19, P4462
[6]   Subventricular zone astrocytes are neural stem cells in the adult mammalian brain [J].
Doetsch, F ;
Caillé, I ;
Lim, DA ;
García-Verdugo, JM ;
Alvarez-Buylla, A .
CELL, 1999, 97 (06) :703-716
[7]  
Doetsch F, 1997, J NEUROSCI, V17, P5046
[8]   Transplantation of mammalian olfactory progenitors into chick hosts reveals migration and differentiation potentials dependent on cell commitment [J].
Durbec, P ;
Rougon, G .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2001, 17 (03) :561-576
[9]   Evidence that perinatal and adult NG2-glia are not conventional oligodendrocyte progenitors and do not depend on axons for their survival [J].
Greenwood, K ;
Butt, AM .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2003, 23 (04) :544-558
[10]   Neuronal fate determinants of adult olfactory bulb neurogenesis [J].
Hack, MA ;
Saghatelyan, A ;
de Chevigny, A ;
Pfeifer, A ;
Ashery-Padan, R ;
Lledo, PM ;
Götz, M .
NATURE NEUROSCIENCE, 2005, 8 (07) :865-872