Changes in rat spleen cannabinoid receptors after chronic CP-55,940: An autoradiographic study

被引:15
作者
Massi, P [1 ]
Patrini, G [1 ]
Rubino, T [1 ]
Fuzio, D [1 ]
Parolaro, D [1 ]
机构
[1] UNIV MILAN,INST PHARMACOL,FAC SCI,I-20129 MILAN,ITALY
关键词
cannabinoids; CP-55,940; chronic treatment; spleen; cannabinoid receptor; down regulation;
D O I
10.1016/S0091-3057(96)00379-6
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
We examined whether cannabinoid receptor density changes in the rat spleen after in vivo chronic exposure to cannabinoids. Rats received daily injections of 0.4 mg/kg IP of the synthetic cannabinoid receptor ligand CP-55,940 for 11 days. One h after the last injection on day 11, the rats were killed and spleen coronal sections were professed for receptor binding autoradiography with 10 nM of [H-3]CP-55,940 in the absence or presence of unlabeled CP-55,940 (10 mu M). Densitometric analysis of the autoradiograms showed significant loss of [H-3]CP-55,940 binding of about 42% in chronic cannabinoid-treated, tolerant rats. Our findings indicate that cannabinoid receptors basically present in immune spleen cells are down-regulated by chronic exposure to cannabinoids, suggesting a role in immune modulation and in the impairment of immune function. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:73 / 78
页数:6
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