Intron length increases oscillatory periods of gene expression in animal cells

被引:106
作者
Swinburne, Ian A. [1 ]
Miguez, David G. [1 ]
Landgraf, Dirk [1 ]
Silver, Pamela A. [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
in vivo quantitation; intron; negative feedback; oscillations; synthetic biology; transcription elongation;
D O I
10.1101/gad.1696108
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Introns may affect gene expression by increasing the time required to transcribe the gene. One way for extended transcription times to affect the behavior of a gene expression program is through a negative feedback loop. Here, we show that a logically engineered negative feedback loop in animal cells produces expression pulses, which have a broad time distribution that increases with intron length. These results in combination with mathematical models provide insight into what may produce the intron-dependent pulse distributions. We conclude that the long production time required for large intron-containing genes is significant for the behavior of gene expression programs.
引用
收藏
页码:2342 / 2346
页数:5
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