Corticotropin-releasing hormone receptor-1 in human endometrial cancer

被引：13

作者：

Graziani, G

Ferrandina, G

Pozzoli, G

Vergati, M

Muzi, A

Legge, F

Tentori, L

Scambia, G

Navarra, P

机构：

[1] Univ Roma Tor Vergata, Dept Neurosci, I-00133 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Sch Med, Dept Obstet Gynecol, Rome, Italy

[3] Univ Cattolica Sacro Cuore, Sch Med, Dept Pharmacol, Rome, Italy

来源：

ONCOLOGY REPORTS | 2006年 / 15卷 / 02期

关键词：

corticotropin-releasing hormone; CRH-R1; alpha; receptor; Ishikawa cell line; estradiol; endometrial adenocarcinoma; human;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We have previously shown that corticotrophinreleasing hormone (CRH) inhibits the proliferation of Ishikawa (IK) human endometrial carcinoma cell line through the activation of CRH-R1 receptors. Here, we have further investigated the role of CRH and its type-1 receptor in the control of IK cell function, and we carried out a pilot study in tumor tissues obtained from 19 patients with endometrial cancer, looking at CRH-R1 gene expression. In the IK study, CRH counteracted the increase in cell proliferation caused by estradiol; type-1 receptors mediating this effect belong to the a subtype. In the study on human tumors, CRH-R1 was expressed in 4 out of 19 (21%) surgical specimens obtained from untreated patients with a diagnosis of primary endometrial cancer. Two out of 4 cases (50%) expressing CRH-R1 mRNA had extrauterine spreading of the disease, whereas cases not expressing CRH-R1 mRNA were all FIGO stage I, 2 (p=0.015).

引用

页码：375 / 379

页数：5

共 18 条

[1]

Regulation of pituitary corticotropin releasing hormone receptors [J].