Rifampin and rifabutin resistance mechanism in Helicobacter pylori

被引：137

作者：

Heep, M

Beck, D

Bayerdörffer, E

Lehn, N

机构：

[1] Univ Dresden, Klinikum Carl Gustav Carus, Dept Internal Med 1, D-01307 Dresden, Germany

[2] Univ Regensburg, Klinikum, Inst Med Mikrobiol, D-93053 Regensburg, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 06期

关键词：

D O I：

10.1128/AAC.43.6.1497

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Eighty-one clinical isolates of Helicobacter pylori showed no resistance to rifampin (MIC range, 0.032 to 2 mu g/ml; MIC at which 50% of isolates are inhibited [MIC50], 0.25 mu g/ml). The MIC50 of rifabutin was 0.008 mu g/ml (n = 16). Alt resistant laboratory mutants of H. pylori ATCC 43504 showed amino acid exchanges in codons 524 to 545 or codon 585 of the rpoB gene, corresponding to the gene sequences from Mycobacterium tuberculosis and Escherichia coli.

引用

页码：1497 / 1499

页数：3

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