Macrocyclic nonviral vectors: High cell transfection efficiency and low toxicity in a lower rim guanidinium calix[4]arene

被引：91

作者：

Bagnacani, Valentina ^{[1
]}

Sansone, Francesco ^{[1
]}

Donofrio, Gaetano ^{[2
]}

Baldini, Laura ^{[1
]}

Casnati, Alessandro ^{[1
]}

Ungaro, Rocco ^{[1
]}

机构：

[1] Univ Parma, Dipartimento Chim Organ & Ind, I-43100 Parma, Italy

[2] Univ Parma, Dipartimento Salute Anim, I-43100 Parma, Italy

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 18期

关键词：

D O I：

10.1021/ol801326d

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

New multivalent cationic lipids, one of them showing high efficiency and low toxicity in cell transfection, have been obtained by attaching guanidinium groups at the lower rim of calix[4]arenes.

引用

页码：3953 / 3956

页数：4

共 31 条

[1]

Progress in gene delivery by cationic lipids: Guanidinium-cholesterol-based systems as an example [J].

Aissaoui, A ;

Oudrhiri, N ;

Petit, L ;

Hauchecorne, M ;

Kan, E ;

Sainlos, M ;

Julia, S ;

Navarro, J ;

Vigneron, JP ;

Lehn, JM ;

Lehn, P .

CURRENT DRUG TARGETS, 2002, 3 (01) :1-16

[2]

Optimizing targeted gene delivery: Chemical modification of viral vectors and synthesis of artificial virus vector systems [J].

Boeckle, Sabine ;

Wagner, Ernst .

AAPS JOURNAL, 2006, 8 (04) :E731-E742

[3]

Lipoplex-mediated delivery of nucleic acids: factors affecting in vivo transfection [J].

Dass, CR .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2004, 82 (09) :579-591

[4]

Gene therapy progress and prospects: magnetic nanoparticle-based gene delivery [J].

Dobson, J .

GENE THERAPY, 2006, 13 (04) :283-287

[5]

Glyconanoparticle-DNA interactions:: An atomic force microscopy study [J].

Eaton, Peter ;

Ragusa, Andrea ;

Clavel, Caroline ;

Rojas, Cristina T. ;

Graham, Paul ;

Duran, Raul V. ;

Penades, Soledad .

IEEE TRANSACTIONS ON NANOBIOSCIENCE, 2007, 6 (04) :309-318

[6]

Guanidinylated neomycin delivers large, bioactive cargo into cells through a heparan sulfate-dependent pathway [J].

Elson-Schwab, Lev ;

Garner, Omai B. ;

Schuksz, Manuela ;

Crawford, Brett E. ;

Esko, Jeffrey D. ;

Tor, Yitzhak .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (18) :13585-13591

[7]

THE ROLE OF DIOLEOYL PHOSPHATIDYLETHANOLAMINE IN CATIONIC LIPOSOME-MEDIATED GENE-TRANSFER [J].

FARHOOD, H ;

SERBINA, N ;

HUANG, L .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1995, 1235 (02) :289-295

[8]

LIPOFECTION - A HIGHLY EFFICIENT, LIPID-MEDIATED DNA-TRANSFECTION PROCEDURE [J].

FELGNER, PL ;

GADEK, TR ;

HOLM, M ;

ROMAN, R ;

CHAN, HW ;

WENZ, M ;

NORTHROP, JP ;

RINGOLD, GM ;

DANIELSEN, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) :7413-7417

[9]

Biologically active bisquaternary ammonium chlorides:: Physico-chemical properties of long chain amphiphiles and their evaluation as non-viral vectors for gene delivery [J].

Fisicaro, E ;

Compari, C ;

Duce, E ;

Donofrio, G ;

Rózycka-Roszak, B ;

Wozniak, E .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2005, 1722 (02) :224-233

[10]

Biophysical properties of CDAN/DOPE-analogue lipoplexes account for enhanced gene delivery [J].

Fletcher, Steven ;

Ahmad, Ayesha ;

Price, Wayne S. ;

Jorgensen, Michael R. ;

Miller, Andrew D. .

CHEMBIOCHEM, 2008, 9 (03) :455-463

← 1 2 3 4 →