Nuclear receptors, bile-acid detoxification, and cholestasis

被引:29
作者
Chen, JZ [1 ]
Raymond, K [1 ]
机构
[1] La Trobe Univ, Fac Sci Technol & Engn, Sch Pharm & Appl Sci, Bendigo, Vic 3550, Australia
关键词
D O I
10.1016/S0140-6736(06)68156-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:454 / 456
页数:3
相关论文
共 20 条
[1]  
BACHS L, 1989, LANCET, V1, P574
[2]   Effects of bile duct ligation on hepatic expression of female-specific CYP2C12 in male and female rats [J].
Chen, JH ;
Robertson, G ;
Field, J ;
Liddle, C ;
Farrell, GC .
HEPATOLOGY, 1998, 28 (03) :624-630
[3]   Bile acids produce a generalized reduction of the catalytic activity of cytochromes P450 and other hepatic microsomal enzymes in vitro: Relevance to drug metabolism in experimental cholestasis [J].
Chen, JZ ;
Farrell, GC .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1996, 11 (09) :870-877
[4]  
Chitturi S, 2001, Semin Gastrointest Dis, V12, P113
[5]   The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp [J].
Denson, LA ;
Sturm, E ;
Echevarria, W ;
Zimmerman, TL ;
Makishima, M ;
Mangelsdorf, DJ ;
Karpen, SJ .
GASTROENTEROLOGY, 2001, 121 (01) :140-147
[6]   No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis [J].
Dilger, K ;
Denk, A ;
Heeg, MHJ ;
Beuers, U .
HEPATOLOGY, 2005, 41 (03) :595-602
[7]   Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis [J].
Fiorucci, S ;
Clerici, C ;
Antonelli, E ;
Orlandi, S ;
Goodwin, B ;
Sadeghpour, BM ;
Sabatino, G ;
Russo, G ;
Castellani, D ;
Willson, TM ;
Pruzanski, M ;
Pellicciari, R ;
Morelli, A .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 313 (02) :604-612
[8]   Regulation of CYP3A4 by the bile acid receptor FXR:: evidence for functional binding sites in the CYP3A4 gene [J].
Gnerre, C ;
Blättler, S ;
Kaufmann, MR ;
Looser, R ;
Meyer, UA .
PHARMACOGENETICS, 2004, 14 (10) :635-645
[9]   Randomised controlled trials of ursodeoxycholic-acid therapy for primary biliary cirrhosis: a meta-analysis [J].
Goulis, J ;
Leandro, G ;
Burroughs, AK .
LANCET, 1999, 354 (9184) :1053-1060
[10]   Farnesoid X receptor activates transcription of the phospholipid pump MDR3 [J].
Huang, L ;
Zhao, A ;
Lew, JL ;
Zhang, T ;
Hrywna, Y ;
Thompson, JR ;
de Pedro, N ;
Royo, I ;
Blevins, RA ;
Peláez, F ;
Wright, SD ;
Cui, JS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (51) :51085-51090