MAP kinases in the immune response

被引：1381

作者：

Dong, C ^{[1
]}

Davis, RJ

Flavell, RA

机构：

[1] Univ Washington, Sch Med, Dept Immunol, Seattle, WA 98195 USA

[2] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA

[3] Univ Massachusetts, Sch Med, Dept Biochem & Mol Biol, Program Mol Med, Worcester, MA 01605 USA

[4] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

[5] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2002年 / 20卷

关键词：

JNK; p38; ERK; innate immunity; helper T cells;

D O I：

10.1146/annurev.immunol.20.091301.131133

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MAP kinases are among the most ancient signal transduction pathways and are widely used throughout evolution in many physiological processes. In mammalian species, MAP kinases are involved in all aspects of immune responses, from the initiation phase of innate immunity, to activation of adaptive immunity, and to cell death when immune function is complete. In this review, we summarize recent progress in understanding the function and regulation of MAP kinase pathways in these phases of immune responses.

引用

页码：55 / 72

页数：18

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