Immunostimulatory activity of cationic-lipid-nucleic-acid complexes against cancer

被引：21

作者：

Dass, CR ^{[1
]}

机构：

[1] Johnson & Johnson Res, Eveleigh 1430, Australia

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2002年 / 128卷 / 04期

关键词：

cationic liposome; lipoplex; oligonucleotide; cancer; immunostimulation;

D O I：

10.1007/s00432-001-0318-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies have highlighted the immunostimulatory nature of nucleic acids and the enhancement of such immunostimulation when nucleic acids are complexed to cationic liposomes to form cationic-lipid-nucleic-acid-complexes or lipoplexes. While such immunostimulation may have deleterious consequences for nucleic acid delivery, especially in the field of gene therapy, it may be harnessed for efficacious usage against the various forms of cancer.

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页码：177 / 181

页数：5

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