Effects of whey protein and resistance exercise on body cell mass, muscle strength, and quality of life in women with HIV

被引:74
作者
Agin, D
Gallagher, D
Wang, J
Heymsfield, SB
Pierson, RN
Kotler, DP
机构
[1] Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Gastrointestinal Div, New York, NY 10025 USA
[2] Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Weight Control Unit, New York, NY 10032 USA
[3] Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Body Composit Unit, New York, NY 10032 USA
[4] Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Div Radiol, New York, NY 10032 USA
关键词
HIV women; body cell mass; whey protein; resistance exercise; quality of life; muscle strength;
D O I
10.1097/00002030-200112070-00011
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective: To determine the effects of whey protein, resistance exercise, and combined protein and exercise treatment on body cell mass (BCM), muscle strength, and quality of life (QOL) in HIV-infected women with reduced BCM. Design and setting: Prospective, randomized, controlled trial at a university hospital in New York City. Methods: A volunteer sample of 30 HIV-infected women were randomized to whey protein (PRO), progressive resistance exercise (PRE), or combined treatment (PRO-PRE) for 14 weeks after a 6-week control period. The main outcome measures were body weight, BCM, skeletal muscle, fat mass, muscle strength, and QOL. Results: There were no significant changes in BCM, strength, or QOL during the control period. PRO patients gained 3.6 kg (P = 0.001), and 2.5 kg fat (P = 0.002) with no change in BCM (0.5 kg; P = 0.07) or skeletal muscle (0.6 kg; P = 0.12). The PRE group increased BCM (0.74 kg;P = 0.03) and skeletal muscle (1.2 kg; P < 0.001) and decreased fat (1.7 kg; P = 0.02). PRO-PRE increased BCM (0.61 kg; P = 0.01) without change in skeletal muscle (0.6 kg; P = 0.30). Strength increased for both exercise groups (range, 40.6-95.3%; P < 0.001). The QOL physical activity score improved for PRE (P = 0.02) and worsened for PRO (P = 0.01). Conclusions: Resistance exercise significantly increased BCM, muscle mass, muscle strength, and QOL in HIV-infected women with reduced BCM. Whey protein had little effect on BCM accrual. Combined protein and exercise did not increase BCM in excess of gains achieved by exercise alone. (C) 2001 Lippincott Williarns & Wilkins.
引用
收藏
页码:2431 / 2440
页数:10
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