Acute renal failure in recipients of organ transplantation and nontransplantation patients: Comparison of characteristics and mortality

被引:12
作者
Johnson, JP [1 ]
Johnston, JR [1 ]
Flick, R [1 ]
Singh, A [1 ]
Angus, D [1 ]
Greenberg, A [1 ]
机构
[1] UNIV PITTSBURGH,SCH MED,DEPT MED,RENAL ELECTROLYTE DIV,PITTSBURGH,PA
关键词
acute renal failure; APACHE II; mortality; transplantation;
D O I
10.3109/08860229709047732
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Mortality from acute renal failure in critically ill patients remains in excess of 50% despite decades of improvement in supportive care. It is not known whether replacement of other failing organs by non-renal organ transplantation affects mortality in acute renal failure. We retrospectively reviewed the course of 169 patients with acute renal failure managed at a single university medical center over a 1-year period. Measures of disease severity (need for renal replacement therapy, mechanical ventilation or parenteral nutrition, presence of oliguria and APA CHE II scores) and final outcome were compared in 97 patients with acute renal failure who did not receive transplants and 72 patients with acute renal failure who underwent non-renal solid organ transplants. Overall mortality was 50.3% and directly correlated with APACHE II score. Compared to nontransplant patients, transplant recipients were younger more frequently male, and less often oliguric; but the groups were similar in mean APACHE II scores and need for renal replacement therapy, prolonged mechanical ventilation, and parenteral nutrition. Overall, mortality was significantly lower for transplant patients compared to nontransplant patients 34.7% vs. 61.9%, p < 0.05). In nonoliguric acute renal failure and renal failure not requiring renal replacement therapy, mortality was low and similar in both transplant and nontransplant patients. Compared to nontransplant patients with similar risk factors and similar APACHE II scores, mortality was significantly lower for transplant patients who were oliguric, and who required renal replacement therapy, mechanical ventilation, or parenteral nutrition. Organ transplantation is associated with a survival advantage in acute renal failure when compared to the outcome of critically ill nontransplant patients. The relation between APACHE II scores and survival is altered by transplantation.
引用
收藏
页码:461 / 473
页数:13
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