A 30-year perspective on alpha(1)-antitrypsin deficiency

被引：53

作者：

Eriksson, S

机构：

[1] Department of Medicine, University of Lund, University Hospital of Malmö, Malmö

[2] Department of Medicine, University Hospital of Malmö

来源：

CHEST | 1996年 / 110卷 / 06期

关键词：

alpha(1)-antitrypsin deficiency; emphysema; endoplasmic reticulum storage diseases; serpins; vasculitic syndromes;

D O I：

10.1378/chest.110.6_Supplement.237S

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The early history of alpha(1)-antitrypsin deficiency, in the years between 1962 and 1965, and its impact on the understanding of emphysema abnormalities were reviewed by me in 1989. This report discusses the disease spectrum (including emphysema, liver, and vasculitic diseases) and focuses on the variable clinical expression of the deficiency state. Some new findings that may be relevant to the function of alpha(1)-antitrypsin are also considered.

引用

收藏

页码：S237 / S242

页数：6

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