Multi-functional nanocarriers for targeted delivery of drugs and genes

被引：135

作者：

Jabr-Milane, Lara ^{[1
]}

van Vlerken, Lilian ^{[2
]}

Devalapally, Harikrishna ^{[3
]}

Shenoy, Dinesh ^{[4
]}

Komareddy, Sushma ^{[5
]}

Bhavsar, Mayank ^{[6
]}

Amiji, Mansoor ^{[1
]}

机构：

[1] Northeastern Univ, Sch Pharm, Dept Pharmaceut Sci, Boston, MA 02115 USA

[2] Cytlmmune Inc, Rockville, MD 20850 USA

[3] NCI, Nanotechnol Charaterizat Labs, Frederick, MD 21702 USA

[4] Novavax Inc, Rockville, MD 20850 USA

[5] Novartis Inst Biomed Res, Cambridge, MA 02139 USA

[6] ArQule Inc, Woburn, MA 01801 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 2008年 / 130卷 / 02期

基金：

美国国家卫生研究院;

关键词：

multi-functional nanocarriers; stimuli-responsive; drug delivery; gene delivery; biological barriers; multi-drug resistance;

D O I：

10.1016/j.jconrel.2008.04.016

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this review article, we describe the different nano-platforms developed in our laboratory at Northeastern University in Boston, MA for the targeted delivery of drugs and genes. Special emphasis is placed on nano-platforms that offer opportunities for multi-functionalization to allow for targeted stimuli-responsive and/or simultaneous strategic delivery of multiple drugs, genes, as well as the combination of therapeutic systems with image contrast enhancers. Polymeric and lipid-based nanocarriers can provide versatile platforms for the delivery of multiple pharmacological agents, specifically to enhance therapeutic effect and overcome drug resistance in cancer. In addition, polymeric nanoparticles and nanoparticles-in-microsphere oral system (NiMOS) are useful for systemic and oral gene therapy, respectively. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：121 / 128

页数：8

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