Multi-functional nanocarriers for targeted delivery of drugs and genes

被引:135
作者
Jabr-Milane, Lara [1 ]
van Vlerken, Lilian [2 ]
Devalapally, Harikrishna [3 ]
Shenoy, Dinesh [4 ]
Komareddy, Sushma [5 ]
Bhavsar, Mayank [6 ]
Amiji, Mansoor [1 ]
机构
[1] Northeastern Univ, Sch Pharm, Dept Pharmaceut Sci, Boston, MA 02115 USA
[2] Cytlmmune Inc, Rockville, MD 20850 USA
[3] NCI, Nanotechnol Charaterizat Labs, Frederick, MD 21702 USA
[4] Novavax Inc, Rockville, MD 20850 USA
[5] Novartis Inst Biomed Res, Cambridge, MA 02139 USA
[6] ArQule Inc, Woburn, MA 01801 USA
基金
美国国家卫生研究院;
关键词
multi-functional nanocarriers; stimuli-responsive; drug delivery; gene delivery; biological barriers; multi-drug resistance;
D O I
10.1016/j.jconrel.2008.04.016
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In this review article, we describe the different nano-platforms developed in our laboratory at Northeastern University in Boston, MA for the targeted delivery of drugs and genes. Special emphasis is placed on nano-platforms that offer opportunities for multi-functionalization to allow for targeted stimuli-responsive and/or simultaneous strategic delivery of multiple drugs, genes, as well as the combination of therapeutic systems with image contrast enhancers. Polymeric and lipid-based nanocarriers can provide versatile platforms for the delivery of multiple pharmacological agents, specifically to enhance therapeutic effect and overcome drug resistance in cancer. In addition, polymeric nanoparticles and nanoparticles-in-microsphere oral system (NiMOS) are useful for systemic and oral gene therapy, respectively. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:121 / 128
页数:8
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