Estrogen receptor gene polymorphisms are associated with recurrence of endometriosis

The presence of gene polymorphisms of the estrogen receptors ER alpha (PvuII and XbaI) and ER beta (AluI) in 61 women with endometriosis was investigated. A statistically significant correlation between PvuII ER alpha gene polymorphism (PvuII), both in homozygosity (PP) and in heterozygosity (Pp), and a recurrence of endometriosis was found. In conclusion, women affected by endometriosis with the ER alpha polymorphic allele, even if heterozygous, have a worse prognosis, and these results suggest that the ER alpha gene polymorphisms. may be included among the genetic risk factors for endometriosis.