Immunogenicity of sequential pneumococcal vaccination in subjects splenectomised for hereditary spherocytosis

被引：29

作者：

Stoehr, GA

Rose, MA

Eber, SW

Heidemann, K

Schubert, R

Zielen, S

机构：

[1] Univ Frankfurt, Dept Surg, D-60590 Frankfurt, Germany

[2] Univ Frankfurt, Childrens Hosp, D-60590 Frankfurt, Germany

[3] Tech Univ Munich, Paediat Off Haematol, D-8000 Munich, Germany

[4] Tech Univ Munich, Childrens Hosp, D-8000 Munich, Germany

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2006年 / 132卷 / 06期

关键词：

hereditary spherocytosis; near total splenectomy; pneumococcal sequential vaccination; pneumococcal conjugate vaccine; 23-valent pneumococcal polysaccharide vaccine;

D O I：

10.1111/j.1365-2141.2005.05918.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Splenectomy predisposes for invasive pneumococcal disease. We investigated the immune response of splenectomised hereditary spherocytosis (HS) patients upon sequential pneumococcal vaccination. Thirty-nine HS-patients (2- to 18-year-old) had undergone near-total or total splenectomy. All received one dose of 7-valent pneumococcal conjugate vaccine (PCV-7) and 23-valent-pneumococcal-polysaccharide vaccine (PPV-23) 2 months apart. Pneumococcal antibodies against serotypes 5/6B/7/14/18C/19F/23F and immunoglobulin serum concentrations were determined before PCV-7 and 4 weeks after PPV-23. Significant rises in antibody geometric mean concentrations were observed after PCV-7 except for serotypes 5 and 7, which increased after PPV-23. We found no impact of the mode of splenectomy.

引用

页码：788 / 790

页数：3

共 11 条

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