Separation and identification of designer drugs with capillary electrophoresis and on-line connection with ionspray mass spectrometry

被引：22

作者：

Gaus, HJ

Gogus, ZZ

Schmeer, K

Behnke, B

Kovar, KA

Bayer, E

机构：

[1] INST ORGAN CHEM,D-72076 TUBINGEN,GERMANY

[2] INST PHARMAZEUT CHEM,D-72076 TUBINGEN,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 735卷 / 1-2期

关键词：

capillary electrophoresis mass spectrometry; enantiomer separation; drugs; methylenedioxyamphetamines; amphetamines;

D O I：

10.1016/0021-9673(95)00965-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The separation of methylenedioxyamphetamine-related designer drugs by capillary zone electrophoresis (CZE) and on-line detection with ionspray mass spectrometry (CZE-MS) is described. CZE-MS coupling permits the fast and reliable identification of this class of substances in the femtomole range. As methylenedioxyamphetamines have an asymmetric carbon atom, several cyclodextrins were investigated as buffer additives for the chiral separation of these compounds.

引用

页码：221 / 226

页数：6

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