Comparative genomics approach to the evolution of eukaryotes and their mitochondria

被引:63
作者
Lang, BF
Seif, E
Gray, MW
O'Kelly, CJ
Burger, G
机构
[1] Univ Montreal, Dept Biochim, Canadian Inst Adv Res, Program Evolutionary Biol, Montreal, PQ H3C 3J7, Canada
[2] Dalhousie Univ, Dept Biochem, Halifax, NS B3H 4H7, Canada
[3] Bigelow Lab Ocean Sci, Boothbay Harbor, ME 04575 USA
关键词
gene order conservation; phylogeny; protists; RNase P RNA;
D O I
10.1111/j.1550-7408.1999.tb04611.x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The Organelle Genome Megasequencing Program (OGMP) investigates mitochondrial genome diversity and evolution by systematically determining the complete mitochondrial DNA (mtDNA) sequences of a phylogenetically broad selection of protists. The mtDNAs of lower fungi and choanoflagellates are being analyzed by the Fungal Mitochondrial Genome Project (FMGP), a sister project to the OGMP. Some of the most interesting protists include the jakobid flagellates Reclinomonas americana, Malawimonas jakobiformis, and Jakoba libera, which share ultrastructural similarities with amitochondriate retortamonads, and harbor mitochondrial genes not seen before in mtDNAs of other organisms. In R. americana and J. libera, gene clusters are found that resemble, to an unprecedented degree, the contiguous ribosomal protein operons str. S10, spc, and alpha of eubacteria. In addition, their mtDNAs code for an RNase P RNA that displays all the elements of a bacterial minimum consensus structure, This structure has been instrumental in detecting the rnpB gene in additional protists. Gene repertoire and gene order comparisons its well as multiple-gene phylogenies support the view of a single endosymbiotic origin of mitochondria, whose closest extant relatives are Rickettsia-type alpha-Proteobacteria.
引用
收藏
页码:320 / 326
页数:7
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