Do Incretins Play a Role in the Remission of Type 2 Diabetes after Gastric Bypass Surgery: What are the Evidence?

被引：97

作者：

Bose, Mousumi ^{[1
]}

Olivan, Blanca ^{[1
]}

Teixeira, Julio ^{[2
]}

Pi-Sunyer, F. Xavier ^{[1
]}

Laferrere, Blandine ^{[1
]}

机构：

[1] Columbia Univ, St Lukes Roosevelt Hosp Ctr, Coll Phys & Surg, New York Obes Res Ctr, New York, NY 10025 USA

[2] Columbia Univ, Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Div Bariatr Surg, New York, NY 10025 USA

来源：

OBESITY SURGERY | 2009年 / 19卷 / 02期

关键词：

Incretin; GLP-1; GIP; Diabetes; Gastric bypass; Insulin; Weight loss; GLUCAGON-LIKE PEPTIDE-1; MORBIDLY OBESE-PATIENTS; BETA-CELL FUNCTION; FASTING PLASMA-GLUCOSE; VERTICAL BANDED GASTROPLASTY; DUODENAL-JEJUNAL EXCLUSION; BODY-WEIGHT REGULATION; ACUTE INSULIN-RESPONSE; LOW-CALORIE DIET; BARIATRIC SURGERY;

D O I：

10.1007/s11695-008-9696-3

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Gastric bypass surgery (GBP), in addition to weight loss, results in dramatic remission of type 2 diabetes (T2DM). The mechanisms by which this remission occurs are unclear. Besides weight loss and caloric restriction, the changes in gut hormones that occur after GBP are increasingly gaining recognition as key players in glucose control. Incretins are gut peptides that stimulate insulin secretion postprandially; the levels of these hormones, particularly glucagon-like peptide-1, increase after GBP in response to nutrient stimulation. Whether these changes are causal to changes in glucose homeostasis remain to be determined. The purpose of this review is to assess the evidence on incretin changes and T2DM remission after GBP, and the possible mechanisms by which these changes occur. Our goals are to provide a thorough update on this field of research so that recommendations for future research and criteria for bariatric surgery can be evaluated.

引用

页码：217 / 229

页数：13

共 141 条

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