Role of the Nlrp3 inflammasome in microbial infection

被引：86

作者：

Anand, Paras K. ^{[1
]}

Malireddi, R. K. Subbarao ^{[1
]}

Kanneganti, Thirumala-Devi ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

FRONTIERS IN MICROBIOLOGY | 2011年 / 2卷

关键词：

NLR; Nlrp3; inflammasome; caspase-1; IL-1; beta; IL-18; NONSELECTIVE CATION CHANNEL; NOD-LIKE RECEPTORS; NALP3; INFLAMMASOME; HOST-DEFENSE; CANDIDA-ALBICANS; ACTIVATE CASPASE-1; INFLUENZA-VIRUS; IMMUNE SENSOR; INNATE; INTERLEUKIN-1-BETA;

D O I：

10.3389/fmicb.2011.00012

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The intracellular Nod-like receptor Nlrp3 has emerged as the most versatile innate immune receptor because of its broad specificity in mediating immune response to a wide range of microbial or danger signals. Nlrp3 mediates assembly of the inflammasome complex in the presence of microbial components leading to the activation of caspase-1 and the processing and release of the pro-inflammatory cytokines IL-1 beta and IL-18. In this review, we give an update on the recent literature examining the role of Nlrp3 inflammasome in response to fungal, bacterial, and viral infections.

引用

页数：6

共 57 条

[1] The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA [J].

Allen, Irving C. ;

Scull, Margaret A. ;

Moore, Chris B. ;

Holl, Eda K. ;

McElvania-TeKippe, Erin ;

Taxman, Debra J. ;

Guthrie, Elizabeth H. ;

Pickles, Raymond J. ;

Ting, Jenny P. -Y. .

IMMUNITY, 2009, 30 (04) :556-565

[2] Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression [J].

Bauernfeind, Franz G. ;

Horvath, Gabor ;

Stutz, Andrea ;

Alnemri, Emad S. ;

MacDonald, Kelly ;

Speert, David ;

Fernandes-Alnemri, Teresa ;

Wu, Jianghong ;

Monks, Brian G. ;

Fitzgerald, Katherine A. ;

Hornung, Veit ;

Latz, Eicke .

JOURNAL OF IMMUNOLOGY, 2009, 183 (02) :787-791

[3] Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin [J].

Boyden, ED ;

Dietrich, WF .

NATURE GENETICS, 2006, 38 (02) :240-244

[4] Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella [J].

Broz, Petr ;

Newton, Kim ;

Lamkanfi, Mohamed ;

Mariathasan, Sanjeev ;

Dixit, Vishva M. ;

Monack, Denise M. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (08) :1745-1755

[5] Host-Detrimental Role of Esx-1-Mediated Inflammasome Activation in Mycobacterial Infection [J].

Carlsson, Fredric ;

Kim, Janice ;

Dumitru, Calin ;

Barck, Kai H. ;

Carano, Richard A. D. ;

Sun, Mei ;

Diehl, Lauri ;

Brown, Eric J. .

PLOS PATHOGENS, 2010, 6 (05) :1-12

[6] Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells [J].

Craven, Robin R. ;

Gao, Xi ;

Allen, Irving C. ;

Gris, Denis ;

Wardenburg, Juliane Bubeck ;

McElvania-TeKippe, Erin ;

Ting, Jenny P. ;

Duncan, Joseph A. .

PLOS ONE, 2009, 4 (10)

[7] TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity [J].

Creagh, Emma M. ;

O'Neill, Luke A. J. .

TRENDS IN IMMUNOLOGY, 2006, 27 (08) :352-357

[8] RETRACTED: Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome (Retracted Article) [J].

Delaloye, Julie ;

Roger, Thierry ;

Steiner-Tardivel, Quynh-Giao ;

Le Roy, Didier ;

Reymond, Marlies Knaup ;

Akira, Shizuo ;

Petrilli, Virginie ;

Gomez, Carmen E. ;

Perdiguero, Beatriz ;

Tschopp, Juerg ;

Pantaleo, Giuseppe ;

Esteban, Mariano ;

Calandra, Thierry .

PLOS PATHOGENS, 2009, 5 (06)

[9]

DIETL P, 1994, MOL PHARMACOL, V45, P300

[10] Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica [J].

Dostert, Catherine ;

Petrilli, Virginie ;

Van Bruggen, Robin ;

Steele, Chad ;

Mossman, Brooke T. ;

Tschopp, Jurg .

SCIENCE, 2008, 320 (5876) :674-677

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