A review on cholinesterase inhibitors for Alzheimer's disease

被引：660

作者：

Anand, Preet ^{[1
]}

Singh, Baldev ^{[1
]}

机构：

[1] Punjabi Univ, Dept Chem, Patiala 147002, Punjab, India

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2013年 / 36卷 / 04期

关键词：

Acetylcholinesterase; Alzheimer's disease; Tacrine; Flavonoid; Donepezil; POTENT ACETYLCHOLINESTERASE INHIBITORS; TACRINE-DIHYDROPYRIDINE HYBRIDS; BETA-AMYLOID AGGREGATION; BIOLOGICAL EVALUATION; HIGHLY POTENT; ACID-DERIVATIVES; DUAL INHIBITORS; FLAVONOID DERIVATIVES; COUMARIN DERIVATIVES; MELATONIN HYBRIDS;

D O I：

10.1007/s12272-013-0036-3

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Alzheimer's disease (AD), a progressive neurodegenerative disorder, is characterized by the deficits in the cholinergic system and deposition of beta amyloid (A beta) in the form of neurofibrillary tangles and amyloid plaques. Since the cholinergic system plays an important role in the regulation of learning and memory processes, it has been targetted for the design of anti-Alzheimer's drugs. Cholinesterase inhibitors enhance cholinergic transmission directly by inhibiting the enzyme acetylcholinesterase (AChE) which hydrolyses acetylcholine. Furthermore, it has been also demonstrated that both acetylcholinesterase and butrylcholinesterase (BuChE) play an important role in A beta-aggregation during the early stages of senile plaque formation. Therefore, AChE and BuChE inhibition have been documented as critical targets for the effective management of AD by an increase in the availability of acetylcholine in the brain regions and decrease in the A beta deposition. This review discusses the different classes of cholinesterase inhibitors including tacrine, donepezil, rivastigmine, galantamine, xanthostigmine, para-aminobenzoic acid, coumarin, flavonoid, and pyrrolo-isoxazole analogues developed for the treatment of AD.

引用

页码：375 / 399

页数：25

共 113 条

[1]

Melatonin role in the mitochondrial function [J].

Acuna-Castroviejo, Dario ;

Escames, Germaine ;

Rodriguez, Maria I. ;

Lopez, Luis C. .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2007, 12 :947-963

[2]

Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE [J].

Alonso, D ;

Dorronsoro, I ;

Rubio, L ;

Muñoz, P ;

García-Palomero, E ;

Del Monte, M ;

Bidon-Chanal, A ;

Orozco, M ;

Luque, FJ ;

Castro, A ;

Medina, M ;

Martínez, A .

BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (24) :6588-6597

[3]

Synthesis and evaluation of novel carbamate-substituted flavanone derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents [J].

Anand, Preet ;

Singh, Baldev .

MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (04) :1648-1659

[4]

Synthesis and evaluation of novel 4-[(3H,3aH,6aH)-3-phenyl)-4,6-dioxo-2-phenyldihydro-2H-pyrrolo[3,4-d] isoxazol-5(3H,6H,6aH)-yl]benzoic acid derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents [J].

Anand, Preet ;

Singh, Baldev .

BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (01) :521-530

[5]

Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil [J].

Andreani, A ;

Cavalli, A ;

Granaiola, M ;

Guardigli, M ;

Leoni, A ;

Locatelli, A ;

Morigi, R ;

Rambaldi, M ;

Recanatini, M ;

Roda, A .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (23) :4011-4014

[6]

Medicinal chemistry approaches for the treatment and prevention of Alzheimer disease [J].

Bachurin, SO .

MEDICINAL RESEARCH REVIEWS, 2003, 23 (01) :48-88

[7]

Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres:: A new class of potent and selective acetylcholinesterase inhibitors [J].

Barreiro, EJ ;

Camara, CA ;

Verli, H ;

Brazil-Más, L ;

Castro, NG ;

Cintra, WM ;

Aracava, Y ;

Rodrigues, CR ;

Fraga, CAM .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (07) :1144-1152

[8]

β-amyloid aggregation induced by human acetylcholinesterase:: inhibition studies [J].

Bartolini, M ;

Bertucci, C ;

Cavrini, V ;

Andrisano, V .

BIOCHEMICAL PHARMACOLOGY, 2003, 65 (03) :407-416

[9]

Cholinesterase inhibitors:: Xanthostigmine derivatives blocking the acetylcholinesterase-induced β-amyloid aggregation [J].

Belluti, F ;

Rampa, A ;

Piazzi, L ;

Bisi, A ;

Gobbi, S ;

Bartolini, M ;

Andrisano, V ;

Cavalli, A ;

Recanatini, M ;

Valenti, P .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (13) :4444-4456

[10]

Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-β aggregation [J].

Bolognesi, ML ;

Andrisano, V ;

Bartolini, M ;

Banzi, R ;

Melchiorre, C .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (01) :24-27

← 1 2 3 4 5 6 7 8 9 10 →