Efficient and highly stereoselective synthesis of a β-lactam inhibitor of the serine protease prostate-specific antigen

被引：34

作者：

Annunziata, R

Benaglia, M

Cinquini, M

Cozzi, F

Puglisi, A

机构：

[1] Univ Milan, Ctr CNR, I-20133 Milan, Italy

[2] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0968-0896(02)00017-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient synthesis of a beta-lactam precursor of the serine protease, prostate-specific antigen inhibitor 1 has been accomplished. The synthesis relies on two completely stercoselective reactions that allow the introduction of the stereocenters at C-3 and C-4 of the azetidinone ring in a predictable manner. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：1813 / 1818

页数：6

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