Acute graft versus host disease following liver transplantation: The enemy within

被引：127

作者：

Taylor, AL ^{[1
]}

Gibbs, P ^{[1
]}

Bradley, JA ^{[1
]}

机构：

[1] Univ Cambridge, Sch Clin Med, Dept Surg, Cambridge, England

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2004年 / 4卷 / 04期

关键词：

Graft vs. host disease; liver transplantation;

D O I：

10.1111/j.1600-6143.2004.00406.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

This article reviews acute graft vs. host disease (GVHD) as a complication of orthotopic liver transplantation (OLT). The incidence, presentation, clinical course and outcome of GVHD after OLT are summarized and the pathogenesis is discussed, drawing parallels with GVHD after allogeneic haematopoietic stem cell transplantation. Risk factors for GVHD after OLT are examined and the potential role of donor lymphocyte macrochimerism in the recipient peripheral blood as a diagnostic aid for GVHD is discussed. Finally, treatment of GVHD after OLT is reviewed with particular emphasis on the potential role of some of the newer biological agents.

引用

页码：466 / 474

页数：9

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