Can menopausal hormone therapy prevent coronary heart disease?

被引：12

作者：

Brinton, Eliot A. ^{[1
]}

Hodis, Howard N. ^{[2
,3
]}

Merriam, George R. ^{[4
,5
]}

Harman, S. Mitchell ^{[6
,7
]}

Naftolin, Frederick ^{[8
]}

机构：

[1] Univ Utah, Sch Med, Salt Lake City, UT 84108 USA

[2] Univ So Calif, Atherosclerosis Res Unit, Dept Med, Los Angeles, CA 90089 USA

[3] Univ So Calif, Atherosclerosis Res Unit, Dept Prevent Med, Los Angeles, CA 90089 USA

[4] VA Puget Sound Hlth Care Syst, Seattle, WA 98493 USA

[5] Univ Washington, Sch Med, Seattle, WA 98493 USA

[6] Kronos Longev Res Inst, Phoenix, AZ 85016 USA

[7] Univ Arizona, Coll Med, Phoenix, AZ 85016 USA

[8] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY 10016 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2008年 / 19卷 / 06期

关键词：

D O I：

10.1016/j.tem.2008.03.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

observational studies show that women who take menopausal hormone therapy (MHT) have a greatly reduced risk of coronary heart disease (CHD). But in some large randomized controlled trials, MHT failed to decrease CHD and so has been deemed inappropriate for long-term prophylaxis against atherosclerosis or other chronic diseases associated with the menopause. Despite the apparent strength of this conclusion, several recent reports suggest that MHT could be atheroprotective when started close to the menopause, and effects of early discontinuation of MHT have never been studied in randomized trials. Here, we examine these reports and highlight existing uncertainty regarding the effects of long-term continuation versus early discontinuation of early-start MHT on atherosclerosis and CHD risk. We call for new research on this question, and an evidence-based review of existing recommendations for MHT.

引用

页码：206 / 212

页数：7

共 60 条

[1] Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosis [J].

Adams, MR ;

Golden, DL ;

Wagner, JD ;

Williams, JK .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (01) :217-221

[2] Effects of conjugated, equine estrogen in postmenopausal women with hysterectomy - The women's health initiative randomized controlled trial [J].

Anderson, GL ;

Limacher, M ;

Assaf, AR ;

Bassford, T ;

Beresford, SAA ;

Black, H ;

Bonds, D ;

Brunner, R ;

Brzyski, R ;

Caan, B ;

Chlebowski, R ;

Curb, D ;

Gass, M ;

Hays, J ;

Heiss, G ;

Hendrix, S ;

Howard, BV ;

Hsia, J ;

Hubbell, A ;

Jackson, R ;

Johnson, KC ;

Judd, H ;

Kotchen, JM ;

Kuller, L ;

LaCroix, AZ ;

Lane, D ;

Langer, RD ;

Lasser, N ;

Lewis, CE ;

Manson, J ;

Margolis, K ;

Ockene, J ;

O'Sullivan, MJ ;

Phillips, L ;

Prentice, RL ;

Ritenbaugh, C ;

Robbins, J ;

Rossouw, JE ;

Sarto, G ;

Stefanick, ML ;

Van Horn, L ;

Wactawski-Wende, J ;

Wallace, R ;

Wassertheil-Smoller, S .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (14) :1701-1712

[3] Quality of life after the menopause: a population study [J].

Blumel, JE ;

Castelo-Branco, C ;

Binfa, L ;

Gramegna, G ;

Tacla, X ;

Aracena, B ;

Cumsille, MA ;

Sanjuan, A .

MATURITAS, 2000, 34 (01) :17-23

[4] Hormone therapy and venous thromboembolism among postmenopausal women -: Impact of the route of estrogen administration and progestogens:: The ESTHER study [J].

Canonico, Marianne ;

Oger, Emmanuel ;

Plu-Bureau, Genevieve ;

Conard, Jacqueline ;

Meyer, Guy ;

Levesque, Herve ;

Trillot, Nathalie ;

Barrellier, Marie-Therese ;

Wahl, Denis ;

Emmerich, Joseph ;

Scarabin, Pierre-Yves .

CIRCULATION, 2007, 115 (07) :840-845

[5] Unopposed estrogen therapy and the risk of invasive breast cancer [J].

Chen, WY ;

Manson, JE ;

Hankinson, SE ;

Rosner, B ;

Holmes, MD ;

Willett, WC ;

Colditz, GA .

ARCHIVES OF INTERNAL MEDICINE, 2006, 166 (09) :1027-1032

[6] A study of hormone replacement therapy in postmenopausal women with ischaemic heart disease: the Papworth HRT Atherosclerosis Study [J].

Clarke, SC ;

Kelleher, J ;

Lloyd-Jones, H ;

Slack, M ;

Schofield, PM .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2002, 109 (09) :1056-1062

[7] Inhibition of postmenopausal atherosclerosis progression: A comparison of the effects of conjugated equine estrogens and soy phytoestrogens [J].

Clarkson, TB ;

Anthony, MS ;

Morgan, TM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (01) :41-47

[8]

Diano S, 1999, MENOPAUSE, V6, P21

[9] Failure of estrogen plus progestin therapy for prevention [J].

Fletcher, SW ;

Colditz, GA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (03) :366-368

[10] Development of low-dose reproductive hormone therapies in China [J].

Ge, Qinsheng ;

Tian, Qinjie ;

Tseng, Hung ;

Naftolin, Frederick .

GYNECOLOGICAL ENDOCRINOLOGY, 2006, 22 (11) :636-645

← 1 2 3 4 5 6 →