Antiproliferative activity of flavonoids on several cancer cell lines

被引：298

作者：

Kawaii, S ^{[1
]}

Tomono, Y ^{[1
]}

Katase, E ^{[1
]}

Ogawa, K ^{[1
]}

Yano, M ^{[1
]}

机构：

[1] Natl Inst Fruit Tree Sci, Shizuoka 4240204, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1999年 / 63卷 / 05期

关键词：

antiproliferative activity; flavonoids; cancer cell lines; human umbilical vein endothelial cells; human foreskin keratinocytes;

D O I：

10.1271/bbb.63.896

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twenty-seven Citrus flavonoids were examined for their antiproliferative activities against several tumor and normal human cell lines. As a result, 7 flavonoids were judged to be active against the tumor cell lines, while they had weak antiproliferative activity against the normal human cell lines. The rank order of potency was luteolin, natsudaidain, quercetin, tangeretin, eriodictyol, nobiletin, and 3,3',4',5,6,7,8-heptamethoxyflavone. The structure-activity relationship established from comparison among these flavones and flavanones showed that the ortho-catechol moiety in ring B and a C2-C3 double bond were important for the antiproliferative activity. As to polymethoxylated flavones. C-3 hydroxyl and C-8 methoxyl groups were essential for high activity.

引用

页码：896 / 899

页数：4

共 20 条

[1] FLAVONOIDS FROM KOELREUTERIA-HENRYI AND OTHER SOURCES AS PROTEIN-TYROSINE KINASE INHIBITORS [J].