In vitro and in vivo activities of tea catechins against Helicobacter pylori

被引：185

作者：

Mabe, K

Yamada, M

Oguni, I

Takahashi, T

机构：

[1] Yamagata Univ, Sch Med, Dept Internal Med 2, Yamagata 9909585, Japan

[2] Hamamatsu Med Ctr, Gastrointestinal Div, Hamamatsu, Shizuoka 4328002, Japan

[3] Univ Shizuoka, Hamamatsu Coll, Dept Nutr & Food Sci, Hamamatsu, Shizuoka 4328012, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 07期

关键词：

D O I：

10.1128/AAC.43.7.1788

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The catechin epigallocatechin gallate showed the strongest activity of the six tea catechins tested against Helicobacter pylori (MIC for 50% of the strains tested, 8 mu g/ml). It had bactericidal activity at pH 7 but not at pH less than or equal to 5.0. In infected Mongolian gerbils, H. pylori was eradicated in 10 to 36% of the catechin-treated animals, with significant decreases in mucosal hemorrhage and erosion. Tea catechins, therefore, may have therapeutic effects on H. pylori infection.

引用

页码：1788 / 1791

页数：4

共 24 条

[1] RELATIONSHIP OF HELICOBACTER-PYLORI TO SERUM PEPSINOGENS IN AN ASYMPTOMATIC JAPANESE POPULATION [J].