A short field guide to fibroblast function in immunity

被引：100

作者：

Buechler, Matthew B. ^{[1
]}

Turley, Shannon J. ^{[1
]}

机构：

[1] Genentech Inc, Dept Canc Immunol, San Francisco, CA 94080 USA

来源：

SEMINARS IN IMMUNOLOGY | 2018年 / 35卷 / 0C期

关键词：

Fibroblast; Fibroblastic reticular cell; Immunity; HEPATIC STELLATE CELLS; HUMAN LUNG FIBROBLASTS; TERTIARY LYMPHOID ORGANS; CXC CHEMOKINE RECEPTOR-5; TISSUE-INDUCER CELLS; REGULATORY T-CELLS; RETICULAR CELLS; STROMAL CELLS; MESENCHYMAL STEM; GENE-EXPRESSION;

D O I：

10.1016/j.smim.2017.11.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Fibroblasts in secondary lymphoid organs, or fibroblastic reticular cells (FRC), are gate-keepers of immune responses. Here, we frame how these cells regulate immune responses via a three-part scheme in which FRC can setup, support or suppress immune responses. We also review how fibroblasts from non-lymphoid tissues influence immunity and highlight how they resemble and differ from FRC. Overall, we aim to focus attention on the emerging roles of lymphoid tissue and non-lymphoid tissue fibroblasts in control of innate and adaptive immunity.

引用

页码：48 / 58

页数：11

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