Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population

被引：11

作者：

Ambrósio, AM

Kennedy, JL

Macciardi, F

Macedo, A

Valente, J

Dourado, A

Oliveira, CR

Pato, C

机构：

[1] Univ Coimbra, Ctr Neurosci, Fac Med, Dept Neurochem, P-3004517 Coimbra, Portugal

[2] Univ Toronto, Neurogenet Sect, Ctr Addict & Mental Hlth, Toronto, ON, Canada

[3] Univ Coimbra, Fac Med, Dept Med Psychol, Coimbra, Portugal

[4] SUNY Syracuse, Upstate Med Univ, Ctr Psychiat & Mol Genet, Syracuse, NY USA

[5] Behav Hlth Care Line, Vet Adm, Syracuse, NY USA

来源：

PSYCHIATRY RESEARCH | 2004年 / 125卷 / 03期

基金：

英国医学研究理事会;

关键词：

schizophrenia; association study; candidate genes; linkage disequilibrium; haplotypes;

D O I：

10.1016/j.psychres.2003.12.016

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Schizophrenia is a highly heritable condition, as demonstrated in family, twin and adoption studies. Candidate genes from the dopaminergic system have long been hypothesized to be involved in the etiology of this disorder. In the present study, we investigated the genetic association between polymorphisms in the D2 and D3 dopamine receptor (DRD2, DRD3) genes and schizophrenia. We examined 90 trios from Portugal, and negative results were obtained from association studies with both Haplotype Relative Risk (HRR) and Transmission Disequilibrium Test (TDT), as well as TRANSMIT. Therefore, we conclude that neither the DRD2 nor the DRD3 gene polymorphisms investigated are associated with schizophrenia in our sample. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：185 / 191

页数：7

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