The synthesis of novel analogues of the manumycin family of antibiotics and the antitumour antibiotic LL-C10037 alpha

被引：26

作者：

Kapfer, I ^{[1
]}

Lewis, NJ ^{[1
]}

Macdonald, G ^{[1
]}

Taylor, RJK ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,TONBRIDGE TN11 9AN,KENT,ENGLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 12期

关键词：

D O I：

10.1016/0040-4039(96)00203-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient approaches to the central amino-epoxycyclohexenone core of the manumycin family of antibiotics are described, The use of this methodology to prepare the antitumour antibiotic LL-C10037 alpha and its epimer, both in racemic form, and a number of analogues of manumycin, alisamycin and asukamycin, lacking the C-4 substituent, ate then outlined.

引用

页码：2101 / 2104

页数：4

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