Genetics of IL-13 and functional relevance of IL-13 variants

被引：51

作者：

Vercelli, Donata ^{[1
,2
]}

机构：

[1] Univ Arizona, Coll Med, Arizona Resp Ctr, Funct Genom Lab, Tucson, AZ 85724 USA

[2] Univ Arizona, Coll Med, Dept Cell Biol & Anat, Tucson, AZ 85724 USA

来源：

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY | 2002年 / 2卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1097/00130832-200210000-00004

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Studies in both humans and mice clearly show that interleukin (IL)-13 is a central regulator of allergic inflammation. Numerous single nucleotide polymorphisms have been recently identified in the IL-13 gene and have been found to be associated with allergic and/or asthmatic phenotypes in different populations throughout the world. Furthermore, functional genomics studies are highlighting mechanistic pathways that may link genetic variation in IL-13 and disease. IL-13 is therefore an ideal model to study the impact of genetic variation on the regulation of gene expression and function in complex diseases. (C) 2002 Lippincott Williams & Wilkins.

引用

页码：389 / 393

页数：5

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