Chromatin remodeling and transcription

被引：176

作者：

Tsukiyama, T ^{[1
]}

Wu, C ^{[1
]}

机构：

[1] NCI,MOL CELL BIOL LAB,NIH,BETHESDA,MD 20892

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(97)80127-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent advances highlight two important chromatin remodeling systems involved in the transcriptional process. One system includes several members of the evolutionarily conserved SWI2/SNF2 family found in distinct multiprotein complexes with ATP-dependent nucleosome destabilizing activity; the other is the enzymatic system that governs histone acetylation and deacetylation. Identification of the catalytic subunits of these opposing histone-modifying activities reveal conserved proteins defined genetically as transcriptional regulators.

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页码：182 / 191

页数：10

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