Delta(9)-tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain

被引：54

作者：

Burkey, TH

Quock, RM

Consroe, P

Roeske, WR

Yamamura, HI

机构：

[1] UNIV ARIZONA,HLTH SCI CTR,COLL MED,DEPT PHARMACOL,TUCSON,AZ 85724

[2] UNIV ARIZONA,HLTH SCI CTR,DEPT PHARMACOL & TOXICOL,TUCSON,AZ 85724

[3] UNIV ARIZONA,HLTH SCI CTR,DEPT BIOCHEM,TUCSON,AZ 85724

[4] UNIV ARIZONA,HLTH SCI CTR,DEPT PSYCHIAT,TUCSON,AZ 85724

[5] UNIV ARIZONA,HLTH SCI CTR,PROGRAM NEUROSCI,TUCSON,AZ 85724

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 323卷 / 2-3期

关键词：

brain; mouse; Delta(9)-tetrahydrocannabinol; G-protein;

D O I：

10.1016/S0014-2999(97)00146-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We measured the ability of the cannabinoid agonists Delta(9)-tetrahydrocannabinol and R(+)-[2,3,-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-naphthalenyl) methanone mesylate (WIN 55,212-2) to stimulate guanosine 5'-O-(3-[S-35]thio)triphosphate ([S-35]GTP gamma S) binding in mouse brain membranes. Delta(9)-Tetrahydrocannabinol stimulated [S-35]GTP gamma S binding by about 25% as compared to WIN 55,212-2. This is the first report demonstrating that Delta(9)-tetrahydrocannabinol acts as a partial agonist in stimulating [S-35]GTP gamma S binding in the mouse brain.

引用

页码：R3 / R4

页数：2

共 8 条

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