Survival in Elderly Persons with Down Syndrome

被引：80

作者：

Coppus, Antonia M. W. ^{[1
,2
]}

Evenhuis, Heleen M. ^{[3
]}

Verberne, Gert-Jan ^{[2
]}

Visser, Frank E. ^{[4
]}

Oostra, Ben A.

Eikelenboom, Piet ^{[5
]}

van Gool, Willem A. ^{[5
]}

Janssens, A. Cecile J. W. ^{[6
]}

van Duijn, Cornelia M. ^{[1
]}

机构：

[1] Erasmus MC, Dept Epidemiol & Biostat, NL-3000 CA Rotterdam, Netherlands

[2] Dichterbij Ctr Intellectually Disabled, Gennep, Netherlands

[3] Erasmus MC, Dept Gen Practice, NL-3000 CA Rotterdam, Netherlands

[4] HeerenLoo Midden Nederland Ctr Intellectually Dis, Ermelo, Netherlands

[5] Univ Amsterdam, Acad Med Ctr, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands

[6] Erasmus MC, Dept Publ Hlth, NL-3000 CA Rotterdam, Netherlands

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 2008年 / 56卷 / 12期

关键词：

Down syndrome; survival; Alzheimer's disease; cognitive and functional decline; apolipoprotein E;

D O I：

10.1111/j.1532-5415.2008.01999.x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The longer life expectancy now experienced by persons with Down syndrome (DS) makes it necessary to know the factors influencing survival in older persons with this syndrome. In a prospective longitudinal cohort study of dementia and mortality, 506 persons with DS aged 45 and older were followed for a mean of 4.5 years (range 0.0-7.6 years). Cognitive and social functioning were tested at baseline and annual follow-up. The diagnosis of dementia was determined according to a standardized protocol. Cox proportional hazards modeling was used for survival analysis. Relative preservation of cognitive and functional ability is associated with better survival in this study population. Clinically, the most important disorders in persons with DS that are related to mortality are dementia, mobility restrictions, visual impairment, and epilepsy but not cardiovascular diseases. Also, level of intellectual disability and institutionalization are associated with mortality.

引用

页码：2311 / 2316

页数：6

共 29 条

[1] Diagnosis of dementia in individuals with intellectual disability [J].

Aylward, EH ;

Burt, DB ;

Thorpe, LU ;

Lai, F ;

Dalton, A .

JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 1997, 41 :152-164

[2]

BAIRD PA, 1988, LANCET, V2, P1354

[3] The influence of intellectual disability on life expectancy [J].

Bittles, AH ;

Petterson, BA ;

Sullivan, SG ;

Hussain, R ;

Glasson, EJ ;

Montgomery, PD .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2002, 57 (07) :M470-M472

[4] The four ages of Down syndrome [J].

Bittles, Alan H. ;

Bower, Carol ;

Hussain, Rafat ;

Glasson, Emma J. .

EUROPEAN JOURNAL OF PUBLIC HEALTH, 2007, 17 (02) :221-225

[5] Dementia and mortality in persons with Down's syndrome [J].

Coppus, A. ;

Evenhuis, H. ;

Verberne, G. -J. ;

Visser, F. ;

van Gool, P. ;

Eikelenboom, P. ;

van Duijin, C. .

JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 2006, 50 :768-777

[6] The impact of apolipoprotein E on dementia in persons with Down's syndrome [J].

Coppus, A. M. W. ;

Evenhuis, H. M. ;

Verberne, G. -J. ;

Visser, F. E. ;

Arias-Vasquez, A. ;

Sayed-Tabatabaei, F. A. ;

Vergeer-Drop, J. ;

Eikelenboom, P. ;

van Gool, W. A. ;

van Duijn, C. M. .

NEUROBIOLOGY OF AGING, 2008, 29 (06) :828-835

[7] Sequence of cognitive decline in dementia in adults with Down's syndrome [J].

Devenny, DA ;

Krinsky-McHale, SJ ;

Sersen, G ;

Silverman, WP .

JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 2000, 44 :654-665

[8] Dementia, cognitive impairment and mortality in persons aged 65 and over living in the community: a systematic review of the literature [J].

Dewey, ME ;

Saz, P .

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2001, 16 (08) :751-761

[9] Further evaluation of the Dementia Questionnaire for Persons with Mental Retardation (DMR) [J].

Evenhuis, HM .

JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 1996, 40 :369-373

[10]

EVENHUIS HM, 1992, J INTELL DISABIL RES, V36, P337

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