Clinical significance of the pulmonary vasodilator response during short-term infusion of prostacyclin in primary pulmonary hypertension

被引:84
作者
Raffy, O [1 ]
Azarian, R [1 ]
Brenot, F [1 ]
Parent, F [1 ]
Sitbon, O [1 ]
Petitpretz, P [1 ]
Herve, P [1 ]
Duroux, P [1 ]
DinhXuan, AT [1 ]
Simonneau, G [1 ]
机构
[1] UNIV PARIS SUD,HOP ANTOINE BECLERE,SERV PNEUMOL & REANIMAT RESP,F-92141 CLAMART,FRANCE
关键词
hemodynamics; epoprostenol; survival;
D O I
10.1161/01.CIR.93.3.484
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background The short-term vasodilator response to prostacyclin (PGI(2)) in patients with primary pulmonary hypertension (PPH) is not only unpredictable but also extremely variable in magnitude. In this retrospective study, we attempted to evaluate in a nonselected population of patients with PPH the degree of vasodilatation achieved during short-term infusion of PGI(2) and to investigate whether patients with PPH differed in terms of baseline characteristics and prognoses, according to the level of vasodilatation achieved during initial resting with PGI(2). Methods and Results Between 1984 and 1992, 91 consecutive patients with PPH underwent catheterization of the right side of the heart with a short-term vasodilator trial with PGI(2) (5 to 10 ng . kg(-1). min(-1)). According to the level of vasodilatation achieved during PGI(2) infusion, patients were divided into three groups: nonresponding (NR, n=40), moderately responding (MR, n=42), and highly responding (HR, n=9) patients. All three groups were defined by a decrease in total pulmonary resistance index (TPRi) of <20%, between 20% and 50%, and vasodilator therapy was subsequently started only in MR and HR patients. All patients had long-term oral anticoagulant therapy. The survival rate at 2 years (transplant recipients excluded) was significantly higher in WR patients compared with NR and MR patients (62% versus 38% and 47% survivors, cn. respectively; P<.05). Comparisons between groups showed no significant differences in baseline hemodynamics or clinical characteristics except for a longer time between onset of symptoms and diagnosis tie, first catheterization) of PPH in HR patients than in NR and MR patients (71+/-61 versus 35+/-34 and 21+/-21 months, respectively; P<.05). Conclusions In this study, patients with PPH exhibiting a decrease in TPRi >50% during short-term PGI(2) challenge at the time of diagnosis had longer disease evolutions and better prognoses than patients with a lower vasodilator response.
引用
收藏
页码:484 / 488
页数:5
相关论文
共 27 条
[1]   PRIMARY PULMONARY-HYPERTENSION - CASE SERIES FROM FRANCE [J].
BRENOT, F .
CHEST, 1994, 105 (02) :S33-S36
[2]  
CHARTERS AD, 1970, BRIT HEART J, V32, P130
[3]   SURVIVAL IN PATIENTS WITH PRIMARY PULMONARY-HYPERTENSION - RESULTS FROM A NATIONAL PROSPECTIVE REGISTRY [J].
DALONZO, GE ;
BARST, RJ ;
AYRES, SM ;
BERGOFSKY, EH ;
BRUNDAGE, BH ;
DETRE, KM ;
FISHMAN, AP ;
GOLDRING, RM ;
GROVES, BM ;
KERNIS, JT ;
LEVY, PS ;
PIETRA, GG ;
REID, LM ;
REEVES, JT ;
RICH, S ;
VREIM, CE ;
WILLIAMS, GW ;
WU, M .
ANNALS OF INTERNAL MEDICINE, 1991, 115 (05) :343-349
[4]   PRIMARY PULMONARY HYPERTENSION .1. CLINICAL AND HEMODYNAMIC STUDY [J].
DRESDALE, DT ;
SCHULTZ, M ;
MICHTOM, RJ .
AMERICAN JOURNAL OF MEDICINE, 1951, 11 (06) :686-705
[5]   PRIMARY PULMONARY-HYPERTENSION - NATURAL-HISTORY AND THE IMPORTANCE OF THROMBOSIS [J].
FUSTER, V ;
STEELE, PM ;
EDWARDS, WD ;
GERSH, BJ ;
MCGOON, MD ;
FRYE, RL .
CIRCULATION, 1984, 70 (04) :580-587
[6]   PRIMARY PULMONARY-HYPERTENSION - LENGTH OF SURVIVAL IN PATIENTS REFERRED FOR HEART-LUNG TRANSPLANTATION [J].
GLANVILLE, AR ;
BURKE, CM ;
THEODORE, J ;
ROBIN, ED .
CHEST, 1987, 91 (05) :675-681
[7]   PRIMARY PULMONARY-HYPERTENSION - AN ANALYSIS OF 28 CASES AND A REVIEW OF THE LITERATURE [J].
HUGHES, JD ;
RUBIN, LJ .
MEDICINE, 1986, 65 (01) :56-72
[8]  
KANEMOTO N, 1979, JPN HEART J, V20, P395
[9]  
KRIETT JM, 1991, J HEART LUNG TRANSPL, V10, P491
[10]   PROSTACYCLIN AND PGE1 TREATMENT OF PULMONARY-HYPERTENSION [J].
LONG, WA ;
RUBIN, LJ .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1987, 136 (03) :773-776