Stress induces tRNA cleavage by angiogenin in mammalian cells

被引：421

作者：

Fu, Hanjiang ^{[1
]}

Feng, Junjun ^{[1
]}

Liu, Qin ^{[1
]}

Sun, Fang ^{[1
]}

Tie, Yi ^{[1
]}

Zhu, Jie ^{[1
]}

Xing, Ruiyun ^{[1
]}

Sun, Zhixian ^{[1
]}

Zheng, Xiaofei ^{[1
]}

机构：

[1] Beijing Inst Radiat Med, Beijing 100850, Peoples R China

来源：

FEBS LETTERS | 2009年 / 583卷 / 02期

关键词：

tRNA cleavage; Angiogenin; Stress; RIBONUCLEASE; INHIBITION; EXPRESSION;

D O I：

10.1016/j.febslet.2008.12.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

tRNAs play a central role in protein translation, acting as the carrier of amino acids. By cloning microRNAs, we unexpectedly obtained some tRNA fragments generated by tRNA cleavage in the anticodon loop. These tRNA fragments are present in many cell lines and different mouse tissues. In addition, various stress conditions can induce this tRNA cleavage event in mammalian cells. More importantly, angiogenin (ANG), a member of RNase A superfamily, appears to be the nuclease which cleaves tRNAs into tRNA halves in vitro and in vivo. These results imply that angiogenin plays an important physiological role in cell stress response, except for the known function of inducing angiogenesis. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：437 / 442

页数：6

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