Metazoan MicroRNAs

被引：3416

作者：

Bartel, David P. ^{[1
,2
,3
]}

机构：

[1] Howard Hughes Med Inst, Cambridge, MA 02139 USA

[2] Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA

[3] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA

来源：

CELL | 2018年 / 173卷 / 01期

基金：

美国国家卫生研究院;

关键词：

MESSENGER-RNA DECAY; GENE-EXPRESSION; TARGETED DELETION; MAMMALIAN MICRORNAS; STRUCTURAL BASIS; NUCLEAR EXPORT; NONCODING RNA; C-ELEGANS; TRANSLATIONAL REPRESSION; CAENORHABDITIS-ELEGANS;

D O I：

10.1016/j.cell.2018.03.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

MicroRNAs (miRNAs) are similar to 22 nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs help sculpt the expression of most mRNAs. This article reviews advances in our understanding of the defining features of metazoan miRNAs and their biogenesis, genomics, and evolution. It then reviews how metazoan miRNAs are regulated, how they recognize and cause repression of their targets, and the biological functions of this repression, with a compilation of knockout phenotypes that shows that important biological functions have been identified for most of the broadly conserved miRNAs of mammals.

引用

页码：20 / 51

页数：32

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