Synthetic studies on the thiostrepton family of peptide antibiotics: synthesis of the tetrasubstituted dehydropiperidine and piperidine cores

被引:24
作者
Higashibayashi, S [1 ]
Hashimoto, K [1 ]
Nakata, M [1 ]
机构
[1] Keio Univ, Fac Sci & Technol, Dept Appl Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan
关键词
thiostrepton; piperidines; sulfinimines; stereoselective reduction;
D O I
10.1016/S0040-4039(01)02090-1
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The tetrasubstituted dehydropiperidine and piperidine cores of the thiostrepton family of peptide antibiotics were synthesized which featured the coupling between the azomethine ylide and the enantiopure sulfinimine. and the subsequent stereoselective reduction of the six-membered imine. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:105 / 110
页数:6
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