Industrial application of fuzzy control to large-scale recombinant vitamin B2 production

被引：24

作者：

Horiuchi, J

Hiraga, K

机构：

[1] Kitami Inst Technol, Dept Chem Syst Engn, Kitami, Hokkaido 0908507, Japan

[2] Nippon Roche KK, Fukuroi Factory, Fukuroi, Shizuoka 4370061, Japan

来源：

JOURNAL OF BIOSCIENCE AND BIOENGINEERING | 1999年 / 87卷 / 03期

关键词：

fuzzy control; vitamin B-2; culture phase; large-scale fermentation;

D O I：

10.1016/S1389-1723(99)80047-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A fuzzy control system featuring the identification of culture phases by fuzzy logic was applied to the large-scale recombinant vitamin B-2 (VB2) production at the Fukuroi factory of Nippon Roche, Fukuroi. Prior to actual operation, the knowledge base for fuzzy control was tuned and verified by a simulation system. Only four rules, formulated as IF similar to THEN instructions and membership functions for state variables, are employed to control the feed rate and pH of the fed-batch culture. By applying fuzzy control, total VB2 production and VB2 yield was increased by 6-16% and 4-11% compared with conventional control, respectively. Operating stability was also improved. The large-scale fermenter used for VB2 production has been successfully operated under the control of the fuzzy system for more than 2 years.

引用

页码：365 / 371

页数：7

共 12 条

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