Diagnostic, prognostic, and therapeutic potency of microRNA 21 in the pathogenesis of colon cancer, current status and prospective

被引：50

作者：

Bahreyni, Amirhossein ^{[1
]}

Rezaei, Melika ^{[2
]}

Bahrami, Afsane ^{[3
]}

Khazaei, Majid ^{[4
,5
]}

Fiuji, Hamid ^{[6
]}

Ryzhikov, Mikhail ^{[7
]}

Ferns, Gordon A. ^{[8
]}

Avan, Amir ^{[5
,9
]}

Hassanian, Seyed Mahdi ^{[5
,10
]}

机构：

[1] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Iran

[2] Ferdowsi Univ Mashhad, Dept Biol, Mashhad, Iran

[3] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran

[4] Mashhad Univ Med Sci, Dept Med Physiol, Fac Med, Mashhad, Iran

[5] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran

[6] Payame Noor Univ, Dept Biochem, Mashhad, Iran

[7] Washington Univ, Sch Med, Div Pulm & Crit Care Med, St Louis, MO USA

[8] Brighton & Sussex Med Sch, Div Med Educ, Brighton, Sussex, England

[9] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Mashhad, Iran

[10] Mashhad Univ Med Sci, Dept Med Biochem, Fac Med, Mashhad, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 06期

关键词：

cancer outcome; colorectal cancer; Mir-21; HUMAN COLORECTAL-CANCER; MIR-21; EXPRESSION; PANCREATIC-CANCER; METASTASIS; INVASION; PROLIFERATION; BIOMARKERS; PLASMA; RISK; OLIGONUCLEOTIDES;

D O I：

10.1002/jcp.27580

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Aberrant microRNA (miR) expression is implicated in multiple human malignancies. miR-21, acting as a proto-oncogene, is involved in a variety of cellular processes and tumorigenesis and is frequently overexpressed in some cancer types. Several tumor suppressors, metastatic, and apoptotic genes have been identified as miR-21 targets, including Ras homolog gene family member B, PTEN, Sprouty2, programmed cell death 4, Integrin-beta 4, and E-cadherin thereby regulating tumor growth, invasion, and metastasis. There is a growing evidence that miR-21 expression is associated with clinical outcomes in patients with colorectal cancer (CRC). In this review, we summarize the potential diagnostic, prognostic, and therapeutic values of miR-21 in CRC progression for a better understanding and hence a better management of this disease.

引用

页码：8075 / 8081

页数：7

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