Physico-chemical characterization of meglumine antimoniate

被引：25

作者：

Demicheli, C ^{[1
]}

de Figueiredo, TL

Carvalho, S

Sinesterra, RD

Lopes, JCD

Frézard, F

机构：

[1] Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Biofis & Fisiol, BR-31270901 Belo Horizonte, MG, Brazil

来源：

BIOMETALS | 1999年 / 12卷 / 01期

关键词：

meglumine antimoniate; structure; leishmaniasis;

D O I：

10.1023/A:1009200330741

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The leishmanicidal drug, meglumine antimoniate (MA), has been synthesized by the reaction of antimony oxyhydrated and N-methyl glucamine. Infrared and solid state NMR C-13 analysis of MA and the ligand strongly suggests that antimony binds to N-methyl glucamine through the oxygen of C-3 carbon. Potentiometric titration indicated that, between pH 4.5 and 7.5, MA exists in the zwitterionic form.

引用

页码：63 / 66

页数：4

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